General description

A cell permeable ureido-sulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (K_i = 45 nM and 4.5 nM, respectively) against two other physiologically relevant hCA isoforms (K_i = 5080 nM and 9640 nM for hCA I and hCA II, respectively). It elicits anti-tumor growth effects dose-dependently from 19 to 38 mg/kg in a mouse tumor growth model implanted with MDA-MB-231 LM2-4^Luc+ cells, and demonstrates metastasis inhibition in a mouse metastasis model injected with 4T1 cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Lock, F.E., et al. 2012. Oncogenein press.Pacchiano, F., et al. 2011. J Med Chem.54, 1896.

Packaging

5 mg in Glass bottle

Packaged under inert gas

Warning

Toxicity: Regulatory Review (Z)